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Cardiology Xagena

Very frequent premature ventricular complexes ( PVCs ) may be a reversible cause of dilated cardiomyopathy. A study has reviewed the literature on the consequences of frequent PVCs on myocardial funct ...


A study has evaluated the magnitude of risk of cardiovascular and cerebrovascular morbidity in patients with psoriatic arthritis ( PsA ) compared with the general population through a systematic revie ...


UK researchers have presented a new study that supports the cardiovascular safety of Calcium and Vitamin-D supplementation. The study was based on analysis of the UK Biobank, a very large study comp ...


In a middle-aged population, it was recently shown that the stable vasopressin marker plasma copeptin predicts development of diabetes mellitus, diabetic heart disease and death. Researchers have hyp ...


Minimal data are available regarding the long-term mortality risk of subclinical atherosclerosis using coronary artery calcium ( CAC ) scoring among patients with a family history of coronary artery d ...


Cholesterol Ester Transfer Protein ( CETP ) inhibitors have been developed following the recognition of an association of CETP polymorphisms and changes in HDL-cholesterol in Japan. Dalcetrapib ( R ...


Smokers have lower short-term mortality after acute myocardial infarction ( AMI ) than non-smokers; however, little is known about the long-term effects of smoking on life expectancy after AMI. A st ...


Carboxylesterases, which convert Dabigatran etexilate ( Pradaxa ) to its active form, Dabigatran, have also been shown to influence lipoprotein metabolism, although any pleotropic effects of the drug ...


The FDA ( Food and Drug Administration ) has approved the first pacemaker that does not require the use of wired leads to provide an electrical connection between the pulse-generating device and the h ...


Renal denervation ( RDN ) is a therapy that targets treatment-resistant hypertension ( TRH ). The Symplicity HTN-1 and Symplicity HTN-2 trials reported response rates of more than 80%; however, sh ...


Contrary to current clinical belief, regular Caffeine consumption does not lead to extra heartbeats, which, while common, can lead in rare cases to heart-or stroke-related morbidity and mortality. ...


Pulmonary hypertension ( PH ) in the setting of left-sided valvular heart disease is common, and significantly increases the risk of perioperative morbidity and mortality in patients undergoing aortic ...


Researchers at University of Manchester ( Manchester, UK = previously reported Omega-3 polyunsaturated fatty acids ( n-3PUFAs ) supplementation does not reduce atrial fibrillation following coronary a ...


A study has evaluated the prospective association between circulating 25-hydroxyvitamin D [ 25(OH)D ] and atrial fibrillation risk. 12 303 participants from the Atherosclerosis Risk in Communities ...


Various ablation strategies of persistent atrial fibrillation ( PersAF ) have had disappointing outcomes, despite concerted clinical and research efforts, which could reflect progressive atrial fibril ...


While bleeding is a well-known complication of Warfarin ( Coumadin ) use and is thought to be a contributory cause of treatment discontinuation, studies quantifying this association are limited. The ...


Researchers performed a prospective, randomized clinical study ( PRESAGE ) to assess whether prophylactic treatment with Metoprolol or Losartan, initiated soon after lung cancer surgery in patients wi ...


Treatment of hypertensive patients with beta-blockers reduces heart rate and decreases central blood pressure less than other antihypertensive drugs, implying that reducing heart rate without altering ...


Data on the incidence of new onset atrial fibrillation and flutter ( AF/f ) in patients with acute pericarditis are limited. A gol of a study was to determine the incidence and prognostic significance ...


Recently published clinical guidelines recommend cardiac resynchronisation therapy ( CRT ) for patients with heart failure with reduced left ventricular ejection fraction ( LVEF ) and non-left bundle ...


The association between obesity and prognosis in patients with coronary artery disease ( CAD ) remains uncertain. Researchers undertook a meta-analysis for the effects of body mass index ( BMI ) on mo ...


ST-elevation myocardial infarction ( STEMI ) is frequently associated with reciprocal ST-segment depression in contralateral ECG leads. However, the relationship of the resolution of ST-segment depres ...


Acute myocardial infarction ( AMI ) is the leading cause of death and disability globally. There is increasing evidence from observational studies that influenza infection is associated with acute myo ...


Plasma norepinephrine ( NE ) level can be a guide to mortality in patients with heart failure. A study aimed to evaluate the significance of plasma norepinephrine level compared with plasma natriureti ...


A study has tested the hypothesis that risk factor pattern, treatment and prognosis differ between men and women with heart failure ( HF ) with and without diabetes in the Swedish Heart Failure Regist ...


The Fontan circulation is associated with an increased risk of thromboembolic events ( TEs ). As many as 25% of these thrombotic events result in fatality. More subtle adverse effects on the pulmonary ...


Atrial fibrillation is often asymptomatic, but outcomes require further characterization. The study objective was to investigate the clinical presentation, management, and outcomes in asymptomatic and ...


Currently available antiarrhythmic agents for the treatment of atrial fibrillation have important limitations, leaving an unmet need for safe and effective therapy. Ranolazine is an approved antiang ...


The purpose of the study was to describe the associated baseline features of atrial fibrillation patients with heart failure ( HF ) with reduced and preserved ejection fraction ( HFrEF and HFpEF ). ...


Research presented at EuroEcho-Imaging 2015 raises the possibility that cancer itself may damage heart muscle irrespective of exposure to cancer drug therapies. Researchers ( Venneri L et al ) from t ...


Activation of the endothelin system has been demonstrated in both plasma and lung tissue of PAH ( pulmonary arterial hypertension ) patients. Although it is unclear if the increases in endothelin-1 pl ...


When considering antiplatelet therapy for acute coronary syndrome ( ACS ), it is essential to balance benefits ( less thrombotic / ischaemic events ) versus bleeding risks related to intense platelet ...


Coronary stent thrombosis is a devastating complication after percutaneous coronary intervention ( PCI ). The mechanisms underlying stent thrombosis are multifactorial. Whether the coagulation syste ...


In the Apixaban for Prevention of Acute Ischemic Events ( APPRAISE-2 ) trial, the use of Apixaban ( Eliquis ), when compared with placebo, in high-risk patients with a recent acute coronary syndrome ( ...


In heart failure patients with diabetes mellitus and/or chronic kidney disease, a new, non-steroidal mineralocorticoid receptor antagonist ( MRA ) called Finerenone was no more effective than the curr ...


The immunosuppressant drug Cyclosporine did not improve clinical outcomes compared to placebo in patients receiving percutaneous coronary intervention ( PCI ) for the more severe form of heart attack ...


The American Heart Association Cardiovascular Health ( CVH ) score is inversely associated with cardiovascular disease, but its relations to cardiac remodeling traits and heart failure ( HF ) incidenc ...


Ticagrelor ( Brilinta, Brilique ) administered in the ambulance reduces ischaemic events 24 hours after primary percutaneous coronary intervention ( PCI ), according to findings from the ATLANTIC-H24 ...


A sub-analysis of the PEGASUS-TIMI 54 study, assessing the effect of Ticagrelor ( Brilinta, Brilique ) in reducing atherothrombotic events in post-myocardial infarction patients, based on the time fro ...


The ESC Guidelines for the management of infective endocarditis are published in European Heart Journal, For the first time, the guidelines recommend that an endocarditis team operating in a referenc ...


The landmark Dual Antiplatelet Therapy ( DAPT ) trial revealed an impressive reduction of stent thrombosis and myocardial infarction after prolonged 30-month DAPT compared to the conventional 12-month ...


Non-vitamin K antagonist oral anticoagulants ( NOACs ) are efficacious and safe antithrombotic drugs but the non-availability of an antidote for potential fatal haemorrhagic events is clinically perce ...


Myocardial infarction patients without heart failure derive no benefit from the addition of mineralocorticoid receptor antagonists ( MRA; antimineralocorticoids ), to standard therapy, results of the ...


Researchers from the PATHWAY 3 study have found that the combination of two commonly used diuretics, each at half dose, can significantly reduce blood pressure without the side-effects caused by full ...


The BENEFIT trial has shown that a 40 to 80 day treatment with the antiparasitic medication Benznidazole ( Rochagan, Radanil ) significantly has reduced parasite activity, but not progression of seri ...


The SERVE-HF trial has shown that adaptive servo-ventilation ( ASV ) therapy increases mortality and should not be used to treat central sleep apnoea in heart failure patients with reduced ejection f ...


The 2015 ESC Guidelines on the diagnosis and management of pericardial diseases are published in European Heart Journal. Previous ESC Guidelines on this topic were published in 2004. The pericardiu ...


The combination drug Valsartan / Sacubitril known as LCZ696 ( Entresto ) significantly reduced aortic systolic blood pressure and pulse pressure compared to the standard angiotensin receptor blocker ( ...


The potential benefit of dual antiplatelet therapy beyond 1 year after a myocardial infarction has not been established. Researchers have investigated the efficacy and safety of Ticagrelor ( Brili ...


The 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension are published in the European Heart Journal and the European Respiratory Journal. The document was written joint ...



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