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Cardiology Xagena

Although there are many different antiarrhythmic drugs approved for rhythm management of atrial fibrillation, little comparative effectiveness data exist to guide drug selection. Researchers follow ...


Catheter ablation of ventricular tachycardia in patients with nonischemic dilated cardiomyopathy can be challenging because of the complexity of underlying substrates. Researchers sought to determin ...


Randomized controlled trials ( RCTs ) regarding use of Ranolazine for the prevention and cardioversion of atrial fibrillation have yielded conflicting results. Researchers have conducted a meta-ana ...


Available pharmacological options for rhythm control strategy in atrial fibrillation are limited by sub-optimal efficacy and potentially serious adverse events. The aim of meta-analysis was to det ...


The optimal rhythm management strategy for people with non-paroxysmal ( persistent or long-standing persistent ) atrial fibrilation is currently not well defined. Antiarrhythmic drugs have been the ...


Ondansetron ( Zofran ) is commonly used to treat vomiting in gastroenteritis, but has a United States FDA ( Food and Drug Administration ) black box warning for risk of Q wave to T wave time interval ...


A study has examined patients with chronic kidney disease ( CKD ) in stages 1, 2, 3 and 4, left ventricular dysfunction and automatic implantable cardioverter-defibrillator ( ICD ). The goal was to ...


Sarcoidosis is an important diagnostic consideration in patients with ventricular tachycardia of unknown origin. The clinical course of ventricular tachycardia as the primary presentation in patients ...


In addition to Warfarin ( Coumadin ), there are four non-vitamin K antagonist oral anticoagulants ( NOACs ) available for stroke prevention in non-valvular atrial fibrillation ( NVAF ). There are li ...


Stroke is a rare but serious complication of acute coronary syndrome. At present, no specific score exists to identify patients at higher risk. The aim of a study was to test whether each clinical v ...


After analyzing 10 years of medical tests on more than 2,700 people in a federally funded heart disease study, researchers at Johns Hopkins Medicine and elsewhere conclude that taking Calcium in the f ...


Results from the global phase 3b ENSURE-AF ( EdoxabaN vs warfarin in subjectS UndeRgoing cardiovErsion of AtrialFibrillation ) study of 2,199 patients with non-valvular atrial fibrillation ( NVAF ) un ...


Heart failure is a major health problem worldwide with no proven therapy. Low-dose Dopamine ( LDD ) has been applied to patients with heart failure to enhance diuresis and preserve renal function sinc ...


Ventricular remodeling following myocardial infarction ( MI ) is closely associated with cyclooxygenase-2 ( COX-2 ) expression. 5-methoxytryptophan ( 5-MTP ) was reported to control COX-2 expression. ...


The 2015 Guidelines for Resuscitation recommend Amiodarone ( Cordarone ) as the antiarrhythmic drug of choice in the treatment of resistant ventricular fibrillation or pulseless ventricular tachycardi ...


Heart failure with recovered or improved ejection fraction ( HFiEF ) has been proposed as a new category of heart failure. Whether HFiEF is clinically distinct from heart failure with persistently r ...


A study assessed whether the benefit of Sacubitril / Valsartan ( Entresto ) therapy varied with clinical stability. Despite the benefit of Sacubitril / Valsartan therapy shown in the PARADIGM-HF ( ...


In the prospective, open-label, non-interventional, multicenter RESPONSIfVE study, the effectiveness, response rates and tolerability of Ivabradine ( Corlentor, Procoralan ) with or without beta block ...


Severe mitral stenosis is usually symptomatic and is treated by BMV or surgery, whereas mild to moderate mitral stenosis is usually asymptomatic or mildly symptomatic and managed medically. Patients ...


The aim of the study was to quantify the efficacy of pretreatment with Ivabradine ( Corlentor, Procoralan ) compared to beta-blockers before computed tomography coronary angiography ( CTCA ) via a met ...


Results from the phase 2b ixCELL-DCM clinical study of Ixmyelocel-T in patients with advanced heart failure due to ischemic dilated cardiomyopathy, were presented at the American College of Cardiology ...


Historically, Warfarin ( Coumadin ) or Acetylsalicylic acid ( Aspirin ) have been the recommended therapeutic options for the extended treatment ( more than 3 months ) of venous thromboembolism ( VTE ...


Among patients recently hospitalized with heart failure and reduced left ventricular ejection fraction ( LVEF ), the use of the drug Liraglutide ( Victoza ) did not lead to greater post-hospitalizatio ...


History of bleeding strongly influences decisions for anticoagulation in atrial fibrillation. Researchers have analyzed outcomes in relation to history of bleeding and randomization in ARISTOTLE trial ...


Sexual activity is a central component of intimate relationships, but sexual function may be impaired by coronary heart disease ( CHD ). There have been few representative population-based comparisons ...


Atrial fibrillation affects approximately 2% of the total population. In order to prevent atrial fibrillation recurrences, many anti-arrhythmic drugs are currently available, but most of them are burd ...


The aim of the study was to analyse the effect of the early coadministration of Ivabradine ( Corlentor / Procoralan ) and beta-blockers ( intervention group ) versus beta-blockers alone ( control grou ...


Propafenone ( Rytmonorm; Rythmol ) is a class Ic antiarrhythmic agent. It has the typical chemical structure of a beta-blocker, but human studies on its beta-blocking effects revealed conflicting resu ...


Ibutilide ( Corvert ) is a rapid-acting antiarrhythmic drug with worldwide use for conversion of recent-onset atrial fibrillation. Vernakalant ( Brinavess ), approved in the European Union in 2010, ...


Sotalol ( Sotalex ) and Amiodarone ( Cordarone ) are commonly prescribed antiarrhythmics for the treatment of post-operative atrial fibrillation ( POAF ). Though they are effective in maintaining sinu ...


Amiodarone ( Cordarone ) is known to affect the thyroid, but little is known about thyroid recovery after short-term Amiodarone treatment. Researchers have evaluated the impact of 8 weeks of Amioda ...


The efficacy of short-term antiarrhythmic drugs ( AADs ) use compared with no-AADs prescription after catheter ablation of atrial fibrillation ( AF ) in preventing atrial arrhythmia recurrence is unce ...


Atrial fibrillation is the most common arrhythmia requiring medical treatment and has been associated with enhanced atrial fibrosis and heart failure. Relaxin, an antifibrosis and antiinflammatory p ...


Apixaban ( Eliquis ), a direct factor Xa inhibitor approved for thromboembolic prophylaxis in patients with non-valvular atrial fibrillation, is increasingly used in patients undergoing catheter ablat ...


Among nearly 35,000 initially healthy women who were followed-up for about 20 years, those with new-onset atrial fibrillation had an increased risk of cancer. Atrial fibrillation, the most common c ...


European Society of Cardiology ( ESC ) Guidelines for the diagnosis and treatment of acute and chronic heart failure are published in European Heart Journal and the European Journal of Heart Failure, ...


A new study by researchers at the Intermountain Medical Center Heart Institute in Salt Lake City found that atrial fibrillation patients treated long term with Warfarin had higher rates of dementia, A ...


Very frequent premature ventricular complexes ( PVCs ) may be a reversible cause of dilated cardiomyopathy. A study has reviewed the literature on the consequences of frequent PVCs on myocardial funct ...


A study has evaluated the magnitude of risk of cardiovascular and cerebrovascular morbidity in patients with psoriatic arthritis ( PsA ) compared with the general population through a systematic revie ...


UK researchers have presented a new study that supports the cardiovascular safety of Calcium and Vitamin-D supplementation. The study was based on analysis of the UK Biobank, a very large study comp ...


In a middle-aged population, it was recently shown that the stable vasopressin marker plasma copeptin predicts development of diabetes mellitus, diabetic heart disease and death. Researchers have hyp ...


Minimal data are available regarding the long-term mortality risk of subclinical atherosclerosis using coronary artery calcium ( CAC ) scoring among patients with a family history of coronary artery d ...


Cholesterol Ester Transfer Protein ( CETP ) inhibitors have been developed following the recognition of an association of CETP polymorphisms and changes in HDL-cholesterol in Japan. Dalcetrapib ( R ...


Smokers have lower short-term mortality after acute myocardial infarction ( AMI ) than non-smokers; however, little is known about the long-term effects of smoking on life expectancy after AMI. A st ...


Carboxylesterases, which convert Dabigatran etexilate ( Pradaxa ) to its active form, Dabigatran, have also been shown to influence lipoprotein metabolism, although any pleotropic effects of the drug ...


The FDA ( Food and Drug Administration ) has approved the first pacemaker that does not require the use of wired leads to provide an electrical connection between the pulse-generating device and the h ...


Renal denervation ( RDN ) is a therapy that targets treatment-resistant hypertension ( TRH ). The Symplicity HTN-1 and Symplicity HTN-2 trials reported response rates of more than 80%; however, sh ...


Contrary to current clinical belief, regular Caffeine consumption does not lead to extra heartbeats, which, while common, can lead in rare cases to heart-or stroke-related morbidity and mortality. ...


Pulmonary hypertension ( PH ) in the setting of left-sided valvular heart disease is common, and significantly increases the risk of perioperative morbidity and mortality in patients undergoing aortic ...


Researchers at University of Manchester ( Manchester, UK = previously reported Omega-3 polyunsaturated fatty acids ( n-3PUFAs ) supplementation does not reduce atrial fibrillation following coronary a ...