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Cardiology Xagena

Heart failure is a major health problem worldwide with no proven therapy. Low-dose Dopamine ( LDD ) has been applied to patients with heart failure to enhance diuresis and preserve renal function sinc ...


Ventricular remodeling following myocardial infarction ( MI ) is closely associated with cyclooxygenase-2 ( COX-2 ) expression. 5-methoxytryptophan ( 5-MTP ) was reported to control COX-2 expression. ...


The 2015 Guidelines for Resuscitation recommend Amiodarone ( Cordarone ) as the antiarrhythmic drug of choice in the treatment of resistant ventricular fibrillation or pulseless ventricular tachycardi ...


Heart failure with recovered or improved ejection fraction ( HFiEF ) has been proposed as a new category of heart failure. Whether HFiEF is clinically distinct from heart failure with persistently r ...


A study assessed whether the benefit of Sacubitril / Valsartan ( Entresto ) therapy varied with clinical stability. Despite the benefit of Sacubitril / Valsartan therapy shown in the PARADIGM-HF ( ...


In the prospective, open-label, non-interventional, multicenter RESPONSIfVE study, the effectiveness, response rates and tolerability of Ivabradine ( Corlentor, Procoralan ) with or without beta block ...


Severe mitral stenosis is usually symptomatic and is treated by BMV or surgery, whereas mild to moderate mitral stenosis is usually asymptomatic or mildly symptomatic and managed medically. Patients ...


The aim of the study was to quantify the efficacy of pretreatment with Ivabradine ( Corlentor, Procoralan ) compared to beta-blockers before computed tomography coronary angiography ( CTCA ) via a met ...


Historically, Warfarin ( Coumadin ) or Acetylsalicylic acid ( Aspirin ) have been the recommended therapeutic options for the extended treatment ( more than 3 months ) of venous thromboembolism ( VTE ...


Among patients recently hospitalized with heart failure and reduced left ventricular ejection fraction ( LVEF ), the use of the drug Liraglutide ( Victoza ) did not lead to greater post-hospitalizatio ...


History of bleeding strongly influences decisions for anticoagulation in atrial fibrillation. Researchers have analyzed outcomes in relation to history of bleeding and randomization in ARISTOTLE trial ...


Sexual activity is a central component of intimate relationships, but sexual function may be impaired by coronary heart disease ( CHD ). There have been few representative population-based comparisons ...


Atrial fibrillation affects approximately 2% of the total population. In order to prevent atrial fibrillation recurrences, many anti-arrhythmic drugs are currently available, but most of them are burd ...


The aim of the study was to analyse the effect of the early coadministration of Ivabradine ( Corlentor / Procoralan ) and beta-blockers ( intervention group ) versus beta-blockers alone ( control grou ...


Propafenone ( Rytmonorm; Rythmol ) is a class Ic antiarrhythmic agent. It has the typical chemical structure of a beta-blocker, but human studies on its beta-blocking effects revealed conflicting resu ...


Ibutilide ( Corvert ) is a rapid-acting antiarrhythmic drug with worldwide use for conversion of recent-onset atrial fibrillation. Vernakalant ( Brinavess ), approved in the European Union in 2010, ...


Sotalol ( Sotalex ) and Amiodarone ( Cordarone ) are commonly prescribed antiarrhythmics for the treatment of post-operative atrial fibrillation ( POAF ). Though they are effective in maintaining sinu ...


Amiodarone ( Cordarone ) is known to affect the thyroid, but little is known about thyroid recovery after short-term Amiodarone treatment. Researchers have evaluated the impact of 8 weeks of Amioda ...


The efficacy of short-term antiarrhythmic drugs ( AADs ) use compared with no-AADs prescription after catheter ablation of atrial fibrillation ( AF ) in preventing atrial arrhythmia recurrence is unce ...


Atrial fibrillation is the most common arrhythmia requiring medical treatment and has been associated with enhanced atrial fibrosis and heart failure. Relaxin, an antifibrosis and antiinflammatory p ...


Apixaban ( Eliquis ), a direct factor Xa inhibitor approved for thromboembolic prophylaxis in patients with non-valvular atrial fibrillation, is increasingly used in patients undergoing catheter ablat ...


Among nearly 35,000 initially healthy women who were followed-up for about 20 years, those with new-onset atrial fibrillation had an increased risk of cancer. Atrial fibrillation, the most common c ...


European Society of Cardiology ( ESC ) Guidelines for the diagnosis and treatment of acute and chronic heart failure are published in European Heart Journal and the European Journal of Heart Failure, ...


A new study by researchers at the Intermountain Medical Center Heart Institute in Salt Lake City found that atrial fibrillation patients treated long term with Warfarin had higher rates of dementia, A ...


Very frequent premature ventricular complexes ( PVCs ) may be a reversible cause of dilated cardiomyopathy. A study has reviewed the literature on the consequences of frequent PVCs on myocardial funct ...


A study has evaluated the magnitude of risk of cardiovascular and cerebrovascular morbidity in patients with psoriatic arthritis ( PsA ) compared with the general population through a systematic revie ...


UK researchers have presented a new study that supports the cardiovascular safety of Calcium and Vitamin-D supplementation. The study was based on analysis of the UK Biobank, a very large study comp ...


In a middle-aged population, it was recently shown that the stable vasopressin marker plasma copeptin predicts development of diabetes mellitus, diabetic heart disease and death. Researchers have hyp ...


Minimal data are available regarding the long-term mortality risk of subclinical atherosclerosis using coronary artery calcium ( CAC ) scoring among patients with a family history of coronary artery d ...


Cholesterol Ester Transfer Protein ( CETP ) inhibitors have been developed following the recognition of an association of CETP polymorphisms and changes in HDL-cholesterol in Japan. Dalcetrapib ( R ...


Smokers have lower short-term mortality after acute myocardial infarction ( AMI ) than non-smokers; however, little is known about the long-term effects of smoking on life expectancy after AMI. A st ...


Carboxylesterases, which convert Dabigatran etexilate ( Pradaxa ) to its active form, Dabigatran, have also been shown to influence lipoprotein metabolism, although any pleotropic effects of the drug ...


The FDA ( Food and Drug Administration ) has approved the first pacemaker that does not require the use of wired leads to provide an electrical connection between the pulse-generating device and the h ...


Renal denervation ( RDN ) is a therapy that targets treatment-resistant hypertension ( TRH ). The Symplicity HTN-1 and Symplicity HTN-2 trials reported response rates of more than 80%; however, sh ...


Contrary to current clinical belief, regular Caffeine consumption does not lead to extra heartbeats, which, while common, can lead in rare cases to heart-or stroke-related morbidity and mortality. ...


Pulmonary hypertension ( PH ) in the setting of left-sided valvular heart disease is common, and significantly increases the risk of perioperative morbidity and mortality in patients undergoing aortic ...


Researchers at University of Manchester ( Manchester, UK = previously reported Omega-3 polyunsaturated fatty acids ( n-3PUFAs ) supplementation does not reduce atrial fibrillation following coronary a ...


A study has evaluated the prospective association between circulating 25-hydroxyvitamin D [ 25(OH)D ] and atrial fibrillation risk. 12 303 participants from the Atherosclerosis Risk in Communities ...


Various ablation strategies of persistent atrial fibrillation ( PersAF ) have had disappointing outcomes, despite concerted clinical and research efforts, which could reflect progressive atrial fibril ...


While bleeding is a well-known complication of Warfarin ( Coumadin ) use and is thought to be a contributory cause of treatment discontinuation, studies quantifying this association are limited. The ...


Researchers performed a prospective, randomized clinical study ( PRESAGE ) to assess whether prophylactic treatment with Metoprolol or Losartan, initiated soon after lung cancer surgery in patients wi ...


Treatment of hypertensive patients with beta-blockers reduces heart rate and decreases central blood pressure less than other antihypertensive drugs, implying that reducing heart rate without altering ...


Data on the incidence of new onset atrial fibrillation and flutter ( AF/f ) in patients with acute pericarditis are limited. A gol of a study was to determine the incidence and prognostic significance ...


Recently published clinical guidelines recommend cardiac resynchronisation therapy ( CRT ) for patients with heart failure with reduced left ventricular ejection fraction ( LVEF ) and non-left bundle ...


The association between obesity and prognosis in patients with coronary artery disease ( CAD ) remains uncertain. Researchers undertook a meta-analysis for the effects of body mass index ( BMI ) on mo ...


ST-elevation myocardial infarction ( STEMI ) is frequently associated with reciprocal ST-segment depression in contralateral ECG leads. However, the relationship of the resolution of ST-segment depres ...


Acute myocardial infarction ( AMI ) is the leading cause of death and disability globally. There is increasing evidence from observational studies that influenza infection is associated with acute myo ...


Plasma norepinephrine ( NE ) level can be a guide to mortality in patients with heart failure. A study aimed to evaluate the significance of plasma norepinephrine level compared with plasma natriureti ...


A study has tested the hypothesis that risk factor pattern, treatment and prognosis differ between men and women with heart failure ( HF ) with and without diabetes in the Swedish Heart Failure Regist ...


The Fontan circulation is associated with an increased risk of thromboembolic events ( TEs ). As many as 25% of these thrombotic events result in fatality. More subtle adverse effects on the pulmonary ...



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