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ESC 2019 - THEMIS trial, Ticagrelor plus Aspirin reduce ischaemic events in stable coronary patients with diabetes mellitus


The combination of Ticagrelor ( Brilique ) and Aspirin ( Acetylsalicylic acid ) reduces ischaemic events compared with Aspirin alone in patients with stable coronary artery disease and diabetes.
The THEMIS trial was presented at ESC Congress 2019 and published in the New England Journal of Medicine.

In the overall population studied in THEMIS, the reduction in important ischaemic events was somewhat counterbalanced by the increase in bleeding.
Therefore, it remains critical to identify which patients are at high ischaemic risk, but low bleeding risk, who could benefit from Ticagrelor and Aspirin.

Patients with diabetes often develop coronary artery disease, with millions of such patients worldwide.
Given the global obesity epidemic, rates of diabetes are increasing, in certain parts of the world.
Those with both conditions are at high risk of myocardial infarction, stroke, and amputations, in part due to an excess tendency for the blood to clot. Aspirin is generally used to decrease this risk, but cardiovascular events still occur at a high rate.

The THEMIS trial has examined whether adding the antiplatelet drug Ticagrelor to Aspirin would reduce the risk of thrombotic events in these patients.
The study enrolled 19,220 patients at 1,315 sites across 42 countries in North America, South America, Asia, Africa, Australia, and Europe.
Patients were 50 years or older, had type 2 diabetes, and had stable coronary artery disease ( defined as a history of percutaneous coronary intervention, bypass grafting, or angiographic stenosis of 50% or more in at least one coronary artery ).
Patients with known prior myocardial infarction or stroke were excluded.

Participants were randomly allocated to Ticagrelor versus placebo, both on top of Aspirin. The primary efficacy outcome was the composite of cardiovascular death, myocardial infarction, or stroke.
The primary safety outcome was TIMI ( Thrombolysis in Myocardial Infarction ) major bleeding.
The median follow-up was 39.9 months.

The incidence of the primary efficacy outcome was lower in the Ticagrelor group than in the placebo group ( 7.7% versus 8.5%; hazard ratio [ HR ] 0.90; 95% confidence interval [ CI ] 0.81–0.99; p = 0.038 ).

The incidence of TIMI major bleeding was higher in the Ticagrelor versus placebo group ( 2.2% versus 1.0%; HR 2.32; 95% CI 1.82–2.94; p less than 0.001 ).

There was a significant reduction in the primary endpoint of cardiovascular death, myocardial infaction, and stroke with Ticagrelor versus placebo.
In addition to myocardial infarction and stroke, acute limb ischaemia and major amputations were also reduced with Ticagrelor. Major bleeding was significantly increased.

Pinpointing subgroups of patients who could benefit from Ticagrelor plus Aspirin is crucial. These are the patients at high ischaemic risk, but low bleeding risk.
In particular, those who have previously tolerated dual antiplatelet therapy without any bleeding complications seem to be the best candidates for prolonged therapy with Ticagrelor and Aspirin.

In conclusion, prolonged therapy with Ticagrelor and Aspirin provides substantial gains in reducing the full spectrum of coronary, cerebral, and peripheral ischaemic events in patients with diabetes and stable coronary artery disease with a history of previous coronary artery stenting who have tolerated dual antiplatelet therapy previously without any bleeding. ( Xagena )

Source: European Society of Cardiology ( ESC ) Congress 2019

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