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Guidelines strongly recommend patients with heart failure with reduced ejection fraction ( HFrEF ) be treated with multiple medications proven to improve clinical outcomes, as tolerated. The degree t ...


Beta-blockers are the cornerstone of therapy for heart failure; however, the effects of these drugs on the prognosis of patients with concomitant atrial fibrillation remain controversial. The obje ...


There are no studies of mineralocorticoid receptor antagonist ( MRA ) treatment examining outcome in unselected real-life patients with myocardial infarction and heart failure. There is uncertainty ...


A study has assessed the relationship between atrial fibrillation and outcomes in the TOPCAT ( Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist ) trial, to evaluat ...


Since the precise mechanism(s) of cognitive disorders in patients with atrial fibrillation ( AF ) is not fully known, the optimal way to prevent cognitive dysfunction for a given patient remains to be ...


Longitudinal studies have shown that dementia is more common in patients diagnosed with atrial fibrillation ( AF ) even in the absence of stroke. A meta-analysis of eight prospective studies evaluat ...


It is well established that atrial fibrillation increases the risk of clinical stroke by four- to five-fold, and patients with a clinical history of stroke are at increased risk of developing dementia ...


Evidence suggests that atrial fibrillation ( AF ) is associated with a higher risk for cognitive impairment and dementia, with or without a history of clinical stroke. Two meta-analyses that include ...


Current guidelines advocate the use of marine-derived Omega-3 fatty acids supplements for the prevention of coronary heart disease and major vascular events in people with prior coronary heart disease ...


Although silent myocardial infarction ( SMI ) accounts for about one-half of the total number of myocardial infarctions ( MIs ), the risk of heart failure ( HF ) among patients with silent myocardial ...


Elevated serum uric acid concentration ( SUA ) has been associated with an increased risk of cardiovascular disease, but this may be due to unmeasured confounders. Researchers have examined the as ...


Sacubitril / Valsartan ( Entresto ) has been shown to improve mortality and reduce hospitalizations in patients with heart failure with reduced ejection fraction ( HFrEF ). The effect of combination ...


The quality of evidence regarding patient-centered outcomes in adults with heart failure after Sacubitril combined with Valsartan ( Entresto ) has not been systematically appraised. An analysis ha ...


Given the rapidly increasing use of stimulant medications during pregnancy and among women of reproductive age who may become pregnant inadvertently, there is a need to better understand their safety. ...


Phase 2 results for Ralinepag, an investigational, long-acting, orally administered prostacyclin receptor agonist under development for the treatment of pulmonary arterial hypertension ( PAH ). In t ...